Rotational thromboelastometry in therapy of life threatening bleeding

Rotational thromboelastometry (ROTEM®) – targeted therapy for coagulation management in patients with massive bleeding

Reversal of warfarin in life-threatening bleeding.

To the Editor—I read with interest the article “The benefit of prothrombin complex concentrate in decreasing neurological deterioration in patients with warfarin-associated intracerebral haemorrhage” by Fong et al in the December 2014 issue of the Hong Kong Medical Journal.1 The Australian guidelines for warfarin reversal quoted in the article were outdated.2 The most recent Australian guidelin...

Life-threatening bleeding following Barrett's surveillance biopsies.

rett’s esophagus (BE) surveillance endoscopy. He was initially referred to our centre in 2008 with a diagnosis of high grade dysplasia (HGD) based on random biopsies at a district general hospital. He underwent an uneventful endoscopic mucosal resection for a visible flat lesion (Paris 0-IIa) located 30 cm from the incisors. The need and appropriateness of continuing surveillance [1] was discus...

Life-threatening gastrointestinal bleeding in Klippel-Trenaunay syndrome.

A 28-year-old Hispanic man was brought to the hospital by emergency medical services after several hours of passing bright red blood per rectum. He complained of feeling dizzy and at the emergency center, he continued to pass a large amount of bright red blood per rectum. On admission his hemoglobin was 6.0g/dL. He had a similar episode of bleeding at age 16, which stopped spontaneously and no ...

Enzyme-replacement therapy in life-threatening hypophosphatasia.

BACKGROUND Hypophosphatasia results from mutations in the gene for the tissue-nonspecific isozyme of alkaline phosphatase (TNSALP). Inorganic pyrophosphate accumulates extracellularly, leading to rickets or osteomalacia. Severely affected babies often die from respiratory insufficiency due to progressive chest deformity or have persistent bone disease. There is no approved medical therapy. ENB-...